Piccadilly Circus used to be surrounded by illuminated advertising hoardings on buildings, starting in the early 1900s building now carries them. As of 2008, the site has six illuminated advertising screens above three large retail units, facing Piccadilly Circus on the north side.

Coca-Cola have had a sign at Piccadilly Circus since at least the 1950s.

Sanyo's sign is the oldest out of the six, the current incarnation having been installed in the late 1980s and remaining unchanged ever since.

TDK replaced the space formerly occupied by Kodak in circa 1990. Their sign has remained almost unchanged since.

McDonald's added a sign in the mid-1980s. In 2001 the sign was changed from neon to an animated LED screen.

Samsung replaced a sign for Panasonic in 1994, and the sign was upgraded from neon to LED in 2005.